RT Journal Article
SR Electronic
T1 Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 137984
DO 10.1101/137984
A1 Tomasz Górski
A1 Romain Veltz
A1 Mathieu Galtier
A1 Hélissande Fragnaud
A1 Jennifer S. Goldman
A1 Bartosz Teleńczuk
A1 Alain Destexhe
YR 2018
UL http://biorxiv.org/content/early/2018/11/07/137984.abstract
AB Many neurons possess dendrites enriched with sodium channels and are capable of generating action potentials. However, the role of dendritic sodium spikes remain unclear. Here, we study computational models of neurons to investigate the functional effects of dendritic spikes. In agreement with previous studies, we found that point neurons or neurons with passive dendrites increase their somatic firing rate in response to the correlation of synaptic bombardment for a wide range of input conditions, i.e. input firing rates, synaptic conductances or refractory periods. However, neurons with active dendrites show the opposite behavior: for a wide range of conditions the firing rate decreases as a function of correlation. We found this property in three types of models of dendritic excitability: a Hodgkin-Huxley model of dendritic spikes, a model with integrate-and-fire dendrites, and a discrete-state dendritic model. We conclude that neurons equipped with with fast dendritic spikes confer much broader computational properties to neurons, sometimes opposite to that of point neurons.