TY - JOUR T1 - A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics JF - bioRxiv DO - 10.1101/2020.06.28.175927 SP - 2020.06.28.175927 AU - Nicolas Guyon AU - Leonardo Rakauskas Zacharias AU - Josina Anna van Lunteren AU - Jana Immenschuh AU - Janos Fuzik AU - Antje Märtin AU - Yang Xuan AU - Misha Zilberter AU - Hoseok Kim AU - Konstantinos Meletis AU - Cleiton Lopes-Aguiar AU - Marie Carlén Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/06/29/2020.06.28.175927.abstract N2 - Inhibitory interneurons expressing parvalbumin (PV) in the prefrontal cortex (PFC) are central to excitatory/inhibitory (E/I) balance, generation of gamma oscillations, and cognition. Dysfunction of PV interneurons disrupts information processing and cognitive behavior. Tyrosine receptor kinase B (trkB) signaling is known to regulate the differentiation and maturation of cortical PV interneurons during development, but is also suggested to be involved in the activity and network functions of PV interneurons in the adult brain. Using a novel viral strategy for cell-type and region-specific expression of a dominant negative trkB in adult mice, we show that reduced trkB signaling in PV interneurons in the PFC leads to pronounced morphological, physiological, and behavioral changes. Our results provide evidence for a critical role of trkB signaling in the function of PV interneurons in the adult brain, local network activities central to prefrontal circuit dynamics, and cognitive behavior.Competing Interest StatementThe authors have declared no competing interest. ER -