RT Journal Article
SR Electronic
T1 RNA Atlas of Human Bacterial Pathogens Uncovers Stress Dynamics Linked to Infection
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.29.177147
DO 10.1101/2020.06.29.177147
A1 Kemal Avican
A1 Jehad Aldahdooh
A1 Matteo Togninalli
A1 Jing Tang
A1 Karsten M. Borgwardt
A1 Mikael Rhen
A1 Maria Fällman
YR 2020
UL http://biorxiv.org/content/early/2020/06/29/2020.06.29.177147.abstract
AB Despite being genetically diverse, bacterial pathogens can adapt to similar stressful environments in human host, but how this diversity allows them to achive this is yet not fully understood. Knowledge gained through comparative genomics is insufficient as it lacks the level of gene expression reflecting gene usage. To fill this gap, we investigated the transcriptome of 32 diverse bacterial pathogens under 11 host related stress conditions. We revealed that diverse bacterial pathogens have common responses to similar stresses to a certain extent but mostly employ their unique repertoire with intersections between different stress responses. We also identified universal stress responders which shed light on the nature of antimicrobial targets. In addition, we found that known and unknown putative novel ncRNAs comprised a significant proportion of the responses. All the data is collected in PATHOgenex atlas, providing ample opportunities to discover novel players critical for virulence and maintenance of infection.Competing Interest StatementThe authors have declared no competing interest.