RT Journal Article
SR Electronic
T1 Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.29.133702
DO 10.1101/2020.06.29.133702
A1 Daniel L. McCartney
A1 Josine L. Min
A1 Rebecca C. Richmond
A1 Ake T. Lu
A1 Maria K. Sobczyk
A1 Gail Davies
A1 Linda Broer
A1 Xiuqing Guo
A1 Ayoung Jeong
A1 Jeesun Jung
A1 Silva Kasela
A1 Seyma Katrinli
A1 Pei-Lun Kuo
A1 Pamela R. Matias-Garcia
A1 Pashupati P. Mishra
A1 Marianne Nygaard
A1 Teemu Palviainen
A1 Amit Patki
A1 Laura M. Raffield
A1 Scott M. Ratliff
A1 Tom G. Richardson
A1 Oliver Robinson
A1 Mette Soerensen
A1 Dianjianyi Sun
A1 Pei-Chien Tsai
A1 Matthijs D. van der Zee
A1 Rosie M. Walker
A1 Xiaochuan Wang
A1 Yunzhang Wang
A1 Rui Xia
A1 Zongli Xu
A1 Jie Yao
A1 Wei Zhao
A1 Adolfo Correa
A1 Eric Boerwinkle
A1 Pierre-Antoine Dugué
A1 Peter Durda
A1 Hannah R Elliott
A1 Christian Gieger
A1 The Genetics of DNA Methylation Consortium
A1 Eco J.C. de Geus
A1 Sarah E. Harris
A1 Gibran Hemani
A1 Medea Imboden
A1 Mika Kähönen
A1 Sharon L.R. Kardia
A1 Jacob K. Kresovich
A1 Shengxu Li
A1 Kathryn L. Lunetta
A1 Massimo Mangino
A1 Dan Mason
A1 Andrew M. McIntosh
A1 Jonas Mengel-From
A1 Ann Zenobia Moore
A1 Joanne M. Murabito
A1 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
A1 Miina Ollikainen
A1 James S. Pankow
A1 Nancy L. Pedersen
A1 Annette Peters
A1 Silvia Polidoro
A1 David J. Porteous
A1 Olli Raitakari
A1 Stephen S. Rich
A1 Dale P. Sandler
A1 Elina Sillanpää
A1 Alicia K Smith
A1 Melissa C. Southey
A1 Konstantin Strauch
A1 Hemant Tiwari
A1 Toshiko Tanaka
A1 Therese Tillin
A1 Andre G Uitterlinden
A1 David J. Van Den Berg
A1 Jenny van Dongen
A1 James G. Wilson
A1 John Wright
A1 Idil Yet
A1 Donna Arnett
A1 Stefania Bandinelli
A1 Jordana T. Bell
A1 Alexandra M Binder
A1 Dorret I Boomsma
A1 Wei Chen
A1 Kaare Christensen
A1 Karen N. Conneely
A1 Paul Elliott
A1 Luigi Ferrucci
A1 Myriam Fornage
A1 Sara Hägg
A1 Caroline Hayward
A1 Marguerite Irvin
A1 Jaakko Kaprio
A1 Deborah A. Lawlor
A1 Terho Lehtimäki
A1 Falk W. Lohoff
A1 Lili Milani
A1 Roger L. Milne
A1 Nicole Probst-Hensch
A1 Alex P. Reiner
A1 Beate Ritz
A1 Jerome I. Rotter
A1 Jennifer A. Smith
A1 Jack A. Taylor
A1 Joyce B.J. van Meurs
A1 Paolo Vineis
A1 Melanie Waldenberger
A1 Ian J. Deary
A1 Caroline L. Relton
A1 Steve Horvath
A1 Riccardo E. Marioni
YR 2020
UL http://biorxiv.org/content/early/2020/06/30/2020.06.29.133702.abstract
AB Biological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic architecture underlying epigenetic ageing and its shared genetic contributions with lifestyle factors and longevity.Competing Interest StatementThe authors have declared no competing interest.