TY - JOUR T1 - Genomic architecture and introgression shape a butterfly radiation JF - bioRxiv DO - 10.1101/466292 SP - 466292 AU - Nathaniel B. Edelman AU - Paul B. Frandsen AU - Michael Miyagi AU - Bernardo Clavijo AU - John Davey AU - Rebecca Dikow AU - Gonzalo GarcĂ­a-Accinelli AU - Steven van Belleghem AU - Nick Patterson AU - Daniel E. Neafsey AU - Richard Challis AU - Sujai Kumar AU - Gilson Moreira AU - Camilo Salazar AU - Mathieu Chouteau AU - Brian Counterman AU - Riccardo Papa AU - Mark Blaxter AU - Robert D. Reed AU - Kanchon Dasmahapatra AU - Marcus Kronforst AU - Mathieu Joron AU - Chris D. Jiggins AU - W. Owen McMillan AU - Federica Di Palma AU - Andrew J. Blumberg AU - John Wakeley AU - David Jaffe AU - James Mallet Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/11/08/466292.abstract N2 - We here pioneer a low-cost assembly strategy for 20 Heliconiini genomes to characterize the evolutionary history of the rapidly radiating genus Heliconius. A bifurcating tree provides a poor fit to the data, and we therefore explore a reticulate phylogeny for Heliconius. We probe the genomic architecture of gene flow, and develop a new method to distinguish incomplete lineage sorting from introgression. We find that most loci with non-canonical histories arose through introgression, and are strongly underrepresented in regions of low recombination and low gene density. This is expected if introgressed alleles are more likely to be purged in such regions due to tighter linkage with incompatibility loci. Finally, we identify a hitherto unrecognized inversion, and show it is a convergent structural rearrangement that captures a known color pattern switch locus within the genus. Our multi-genome assembly approach enables an improved understanding of adaptive radiation. ER -