RT Journal Article
SR Electronic
T1 Hingepoints and neural folds reveal conserved features of primary neurulation in the zebrafish forebrain
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 738161
DO 10.1101/738161
A1 Jonathan M. Werner
A1 Maraki Y. Negesse
A1 Dominique L. Brooks
A1 Allyson R. Caldwell
A1 Jafira M. Johnson
A1 Rachel M. Brewster
YR 2020
UL http://biorxiv.org/content/early/2020/06/30/738161.abstract
AB Primary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts such as zebrafish has remained highly debated. Teleosts are thought to have evolved a unique pattern of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds (NFs), at least in the hindbrain/trunk where it has been studied. We report here on zebrafish forebrain morphogenesis where we identify these morphological landmarks. Our findings reveal a deeper level of conservation of neurulation than previously recognized and establish the zebrafish as a model to understand human neural tube development.Competing Interest StatementThe authors have declared no competing interest.