RT Journal Article
SR Electronic
T1 Hashimoto’s Thyroiditis-associated Thyroid Swelling among Adolescents Presenting with Benign Goiter in Lahore, Pakistan
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 468777
DO 10.1101/468777
A1 Saira Shan
A1 Shumaila Aslam
A1 Shan Elahi
A1 Nayab Batool Rizvi
A1 Nazish Saleem
YR 2018
UL http://biorxiv.org/content/early/2018/11/12/468777.abstract
AB Background The aim of this study was to determine frequency of Hashimoto’s thyroiditis (HT), by determination of serum TPO-Ab titer in goitrous adolescents attending Centre for Nuclear Medicine (CENUM), Mayo Hospital, Lahore, Pakistan.Method Serum TPO-Ab was determined in 277 local goitrous adolescents (female 194, male 83) with euthyroidism or subclinical hypothyroidism. Their mean (±SD) age was 15.8 + ***2.5 years with age range 10 to 19 year. Female and male adolescents were comparable in age, goiter size and serum thyroid hormone levels.Results Mean TSH and percentage of TSH levels > 3.0 mIU/L was significantly higher in male adolescents. High serum TPO-Ab titer (> 20.0 IU/ml) or HT was detected in 38 (13.7%) patients. The incidence of HT in female (16.5%) was higher than male adolescents (7.2%) but the difference was not statistically significant (p=0.120). Similarly goiter size (palpable or visible) or patient age (below or above 16 year) has no significant effect on HT frequency. However, compared to adolescents with TSH within normal laboratory range those with TSH level above the upper normal limit (4.0 mIU/L) had significantly more frequency of HT (10.4% versus 30.4%; p=0.001).Conclusion Thus this study reports 13.7% prevalence of HT-associated goiter among local adolescents presenting with benign goiter, in Lahore Pakistan.AbbreviationsAITautoimmune thyroiditisTSHthyroid stimulating hormoneUSIuniversal salt iodizationHTHashimoto’s thyroiditisTPO-Abthyroid peroxidase antibodiesCENUMCentre for Nuclear MedicineFT4free 3, 5, 3/, 5/-tetra-iodothyronineFT3free 3, 5, 37-triiodothyronineELISAEnzyme linked immune sorbent assayRIAradioimmunoassayIRMAimunoradiometric assayCVcumulative variationTgthyroglobulinpmol/Lpico mole per litremIU/Lmilli international unit