RT Journal Article
SR Electronic
T1 Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.22.028613
DO 10.1101/2020.04.22.028613
A1 Xian Zhou
A1 Xingxing Zhu
A1 Chaofan Li
A1 Yanfeng Li
A1 Zhenqing Ye
A1 Virginia Shapiro
A1 John A. Copland III
A1 Taro Hitosugi
A1 David Bernlohr
A1 Jie Sun
A1 Hu Zeng
YR 2020
UL http://biorxiv.org/content/early/2020/07/05/2020.04.22.028613.abstract
AB Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The role of different FA species, and their impacts on humoral immunity remains poorly understood. Here we report that proliferating B cells require monounsaturated FAs (MUFA) to maintain mitochondrial metabolism and mTOR activity, and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell extrinsic Stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.Competing Interest StatementThe authors have declared no competing interest.