RT Journal Article
SR Electronic
T1 Cognitive Benefits of Exercise Interventions: An fMRI Activation Likelihood Estimation Meta-Analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.07.04.187401
DO 10.1101/2020.07.04.187401
A1 Yu, Qian
A1 Herold, Fabian
A1 Becker, Benjamin
A1 KluGah-Brown, Ben
A1 Zhang, Yanjie
A1 Perrey, Stephane
A1 Veronese, Nicola
A1 Müller, Notger G.
A1 Zou, Liye
A1 Kramer, Arthur F.
YR 2020
UL http://biorxiv.org/content/early/2020/07/06/2020.07.04.187401.abstract
AB Despite a growing number of functional MRI studies reporting exercise-induced changes during cognitive processing, a systematic determination of the underlying neurobiological pathways is currently lacking. To this end, our neuroimaging meta-analysis included 20 studies and investigated the influence of exercise on cognition-related functional brain activation. The overall meta-analysis encompassing all experiments revealed exercise-induced changes in the left parietal lobe during cognitive processing. Subgroup analysis further revealed that in the younger-age group (<35 years old) exercise induced more widespread changes in the right hemisphere whereas in the older-age group (≥35 years old) exercise-induced changes were restricted to the left parietal lobe. Furthermore, subgroup analysis for exercise intervention duration, showed that shorter exercise interventions induced changes in regions connected with frontoparietal and default mode networks whereas regions exhibiting effects of longer interventions connected with frontoparietal and dorsal attention networks. Our findings suggest that physical exercise training leads to changes in functional activation patterns primarily located in precuneus and associated with frontoparietal, dorsal attention and default mode networks. Furthermore, exercise-induced changes in functional brain activation varied as a function of age and exercise intervention duration.Competing Interest StatementThe authors have declared no competing interest.