RT Journal Article SR Electronic T1 Proliferation Saturation Index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses JF bioRxiv FD Cold Spring Harbor Laboratory SP 469957 DO 10.1101/469957 A1 Enakshi D. Sunassee A1 Dean Tan A1 Tianlin Ji A1 Renee Brady A1 Eduardo G. Moros A1 Jimmy J. Caudell A1 Slav Yartsev A1 Heiko Enderling YR 2018 UL http://biorxiv.org/content/early/2018/11/14/469957.abstract AB Purpose Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been shown to yield excellent data fits at the cost of nonidentifiability and clinically unrealistic results.Materials and Methods We develop a mathematical model based on a proliferation saturation index (PSI) that is a measurement of pre-treatment tumor volume-to-carrying capacity ratio that modulates intrinsic tumor growth and radiation response rates. In an adaptive Bayesian approach, we utilize an increasing number of data points for individual patients for predicting response to subsequent radiation doses.Results Model analysis shows that using PSI as the only patient-specific parameter, model simulations can fit longitudinal clinical data with high accuracy (R2=0.84). By analyzing tumor response to radiation using daily CT scans early in the treatment, response to the remaining treatment fractions can be predicted after two weeks with high accuracy (c-index=0.89).Conclusion The PSI model may be suited to forecast treatment response for individual patients and offer actionable decision points for mid-treatment protocol adaptation. The presented work provides an actionable image-derived biomarker prior to and during therapy to personalize and adapt radiotherapy.