RT Journal Article
SR Electronic
T1 Non-linear tumor-immune interactions arising from spatial metabolic heterogeneity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 038273
DO 10.1101/038273
A1 Mark Robertson-Tessi
A1 Robert J. Gillies
A1 Robert A. Gatenby
A1 Alexander R. A. Anderson
YR 2016
UL http://biorxiv.org/content/early/2016/05/04/038273.abstract
AB A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect the response of the immune system. The model includes vascular dynamics and evolution of metabolic tumor phenotypes. Cytotoxic T cells are simulated, and their effect on tumor growth is shown to be dependent on the structure of the microenvironment and the distribution of tumor phenotypes. Importantly, no single immune strategy is best at all stages of tumor growth.