RT Journal Article
SR Electronic
T1 Modulation of neural oscillations during working memory update, maintenance, and readout: an hdEEG study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.07.07.191619
DO 10.1101/2020.07.07.191619
A1 Marianna Semprini
A1 Gaia Bonassi
A1 Federico Barban
A1 Elisa Pelosin
A1 Riccardo Iandolo
A1 Michela Chiappalone
A1 Dante Mantini
A1 Laura Avanzino
YR 2020
UL http://biorxiv.org/content/early/2020/07/07/2020.07.07.191619.abstract
AB Working memory (WM) performance is very often measured using the n-back task, in which the participant is presented with a sequence of stimuli, and required to indicate whether the current stimulus matches the one presented n steps earlier. In this study, we used high-density electroencephalography (hdEEG) coupled to source localization to obtain information on spatial distribution and temporal dynamics of neural oscillations associated with WM update, maintenance and readout. Specifically, we a priori selected regions from a large fronto-parietal network, including also the insula and the cerebellum, and we analyzed modulation of neural oscillations by event-related desynchronization and synchronization (ERD/ERS).During update and readout, we found larger θ ERS and smaller β ERS respect to maintenance in all the selected areas. γLOW and γHIGH bands oscillations decreased in the frontal and insular cortices of the left hemisphere. In the maintenance phase we observed focally decreased θ oscillations and increased β oscillations (ERS) in most of the selected posterior areas and focally increased oscillations in γLOW and γHIGH bands in the frontal and insular cortices of the left hemisphere. Finally, during WM readout, we also found a focal modulation of the γLOW band in the left fusiform cortex and cerebellum, depending on the response trial type (true positive vs. true negative).Overall, our study demonstrated specific spectral signatures associated with updating of memory information, WM maintenance and readout, with relatively high spatial resolution.Competing Interest StatementThe authors have declared no competing interest.