TY - JOUR T1 - A new on-line tool for the calculation of bioaccumulation factors of active substances within living organisms: MOSAIC<sub>Bioacc</sub> JF - bioRxiv DO - 10.1101/2020.07.07.185835 SP - 2020.07.07.185835 AU - Aude Ratier AU - Christelle Lopes AU - Gauthier Multari AU - Vanessa Mazerolles AU - Patrice Carpentier AU - Sandrine Charles Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/07/08/2020.07.07.185835.abstract N2 - Today, no effective tools are proposed in ecotoxicology to diagnose and predict the accumulation and effects of chemical substances on living organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolization processes, cocktail effects, etc.). Among elaborated tools, toxicokinetic/toxicodynamic (TKTD) models are now strongly recommended to describe the exposure time-dependency on individual life-history traits from experimental data collected through standard toxicity tests. In particular, the TK part is used to relate the exposure medium concentration to the internal concentration within organisms, considering various processes such as accumulation, depuration, metabolization and excretion (ADME). Regarding plant protection products in marketing authorization applications, regulation No 283/2013 (EU) defines the data requirements for active substances with a bioaccumulation test on fish following OECD guideline 305, which consists in an accumulation phase followed by a depuration phase. The concentration of the substance within fishes is followed over time during both phases thus allowing to describe the exposure time-dependency on individual (fit of TK model) and bioaccumulation factors. On a regulation point of view, these factors are decisive criteria for further estimating the concentration of active substances present in food items of vertebrates and more particularly of piscivorous birds and mammals. This paper presents a new ready-to-use tool providing on-line the estimation of the bioaccumulation factors associated with their uncertainty to facilitate the daily work of regulators, but also of any user, by benefiting of a freely available and user-friendly interface avoiding to invest into underlying methods. This tool, MOSAICBioacc, is available from the following adress: https://mosaic.univ-lyon1.fr/bioacc, and can be used as a turn-key decision making tool in the framework of environmental risk assessment.Competing Interest StatementThe authors have declared no competing interest. ER -