PT  - JOURNAL ARTICLE
AU  - Jayne Morriss
AU  - Carien M. van Reekum
TI  - Knowledge is power: Contingency instruction promotes threat extinction in high intolerance of uncertainty individuals
AID  - 10.1101/470724
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 470724
4099  - http://biorxiv.org/content/early/2018/11/16/470724.short
4100  - http://biorxiv.org/content/early/2018/11/16/470724.full
AB  - Extinction-resistant threat is considered to be a central feature of pathological anxiety. Reduced threat extinction is observed in individuals with high intolerance of uncertainty (IU). Here we sought to determine whether contingency instructions could alter the course threat extinction for individuals high in IU. We tested this hypothesis in two identical experiments (Exp 1 n = 60, Exp 2 n = 82) where we recorded electrodermal activity during threat acquisition with partial reinforcement, and extinction. Participants were split into groups based on extinction instructions (instructed, uninstructed) and IU score (low, high). All groups displayed larger skin conductance responses to learned threat versus safety cues during threat acquisition, indicative of threat conditioning. In both experiments, only the uninstructed high IU groups displayed larger skin conductance responses to the learned threat versus safety cue during threat extinction. These findings suggest that uncertain threat during extinction maintains conditioned responding in individuals high in IU.