RT Journal Article
SR Electronic
T1 Distributed correlates of visually-guided behavior across the mouse brain
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 474437
DO 10.1101/474437
A1 Nicholas A. Steinmetz
A1 Peter Zatka-Haas
A1 Matteo Carandini
A1 Kenneth D. Harris
YR 2018
UL http://biorxiv.org/content/early/2018/11/20/474437.abstract
AB Behavior arises from neuronal activity, but it is not known how the active neurons are distributed across brain regions and how their activity unfolds in time. Here, we used high-density Neuropixels probes to record from ~30,000 neurons in mice performing a visual contrast discrimination task. The task activated 60% of the neurons, involving nearly all 42 recorded brain regions, well beyond the regions activated by passive visual stimulation. However, neurons selective for choice (left vs. right) were rare, and found mostly in midbrain, striatum, and frontal cortex. Those in midbrain were typically activated prior to contralateral choices and suppressed prior to ipsilateral choices, consistent with a competitive midbrain circuit for adjudicating the subject’s choice. A brain-wide state shift distinguished trials in which visual stimuli led to movement. These results reveal concurrent representations of movement and choice in neurons widely distributed across the brain.