PT - JOURNAL ARTICLE AU - Servello, Francesco A. AU - Apfeld, Javier TI - The heat shock transcription factor HSF-1 protects <em>Caenorhabditis elegans</em> from peroxide stress AID - 10.1101/2020.07.13.200634 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.07.13.200634 4099 - http://biorxiv.org/content/early/2020/07/14/2020.07.13.200634.short 4100 - http://biorxiv.org/content/early/2020/07/14/2020.07.13.200634.full AB - Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Using the nematode Caenorhabditis elegans, we show that the heat shock transcription factor HSF-1 protects the nematode from the oxidative stress induced by environmental peroxide. In response to a heat shock or a mild temperature increase, HSF-1 protects the nematodes from subsequent oxidative stress in a manner that depends on HSF-1’s transactivation domain. At constant temperature, HSF-1 protects the nematodes from oxidative stress independently of its transactivation domain, likely by inducing the expression of asp-4/cathepsin D and dapk-1/dapk. Thus, two distinct HSF-1-dependent processes protect C. elegans from oxidative stress.Competing Interest StatementThe authors have declared no competing interest.