PT  - JOURNAL ARTICLE
AU  - Francesco A. Servello
AU  - Javier Apfeld
TI  - The heat shock transcription factor HSF-1 protects <em>Caenorhabditis elegans</em> from peroxide stress
AID  - 10.1101/2020.07.13.200634
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.07.13.200634
4099  - http://biorxiv.org/content/early/2020/07/14/2020.07.13.200634.short
4100  - http://biorxiv.org/content/early/2020/07/14/2020.07.13.200634.full
AB  - Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Using the nematode Caenorhabditis elegans, we show that the heat shock transcription factor HSF-1 protects the nematode from the oxidative stress induced by environmental peroxide. In response to a heat shock or a mild temperature increase, HSF-1 protects the nematodes from subsequent oxidative stress in a manner that depends on HSF-1’s transactivation domain. At constant temperature, HSF-1 protects the nematodes from oxidative stress independently of its transactivation domain, likely by inducing the expression of asp-4/cathepsin D and dapk-1/dapk. Thus, two distinct HSF-1-dependent processes protect C. elegans from oxidative stress.Competing Interest StatementThe authors have declared no competing interest.