TY - JOUR T1 - Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots JF - bioRxiv DO - 10.1101/2020.07.15.203638 SP - 2020.07.15.203638 AU - Isabel Betegón-Putze AU - Josep Mercadal AU - Nadja Bosch AU - Ainoa Planas-Riverola AU - Mar Marquès-Bueno AU - Josep Vilarrasa-Blasi AU - David Frigola AU - Rebecca Corinna Burkart AU - Cristina Martínez AU - Yvonne Stahl AU - Salomé Prat AU - Marta Ibañes AU - Ana I. Caño-Delgado Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/07/16/2020.07.15.203638.abstract N2 - Root growth and development are essential features for plant survival and the preservation of terrestrial ecosystems. In the Arabidopsis primary root apex, stem-cell specific transcription factors BRAVO and WOX5 co-localize at the Quiescent Center (QC) cells, where they repress cell division so that these cells can act as a reservoir to replenish surrounding stem cells, yet their molecular connection remains unknown. Here, by using empirical evidence and mathematical modeling, we establish the precise regulatory and molecular interactions between BRAVO and WOX5. We found that BRAVO and WOX5 regulate each other besides forming a transcription factor complex in the QC necessary to preserve overall root growth and architecture. Our results unveil the importance of transcriptional regulatory circuits at the quiescent and stem cells to the control of organ initiation and growth of plant tissues. ER -