PT  - JOURNAL ARTICLE
AU  - Yoshida, Saiko
AU  - Schuren, Alja van der
AU  - van Dop, Maritza
AU  - van Galen, Luc
AU  - Saiga, Shunsuke
AU  - Adibi, Milad
AU  - Möller, Barbara
AU  - Marhavy, Peter
AU  - Smith, Richard
AU  - Friml, Jiri
AU  - Weijers, Dolf
TI  - A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis
AID  - 10.1101/479113
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 479113
4099  - http://biorxiv.org/content/early/2018/11/27/479113.short
4100  - http://biorxiv.org/content/early/2018/11/27/479113.full
AB  - Multicellular development requires coordinated cell polarization relative to body axes, and translation to oriented cell division. In plants, it is unknown how cell polarities are connected to organismal axes and translated to division. Here, we identify Arabidopsis SOSEKI (SOK) proteins that integrate apical-basal and radial organismal axes to localize to polar cell edges. Localization does not depend on tissue context, requires cell wall integrity and is defined by a transferrable, protein-specific motif. SOK proteins structurally resemble the DIX oligomerization domain in the animal Dishevelled polarity regulator. The DIX-like domain self-interacts and is required for edge localization and for influencing division orientation. Our work identifies a plant compass, interpreted by SOK proteins. Furthermore, despite fundamental differences, polarity in plants and animals converge upon the same protein domain.