RT Journal Article
SR Electronic
T1 A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 479113
DO 10.1101/479113
A1 Yoshida, Saiko
A1 Schuren, Alja van der
A1 van Dop, Maritza
A1 van Galen, Luc
A1 Saiga, Shunsuke
A1 Adibi, Milad
A1 Möller, Barbara
A1 Marhavy, Peter
A1 Smith, Richard
A1 Friml, Jiri
A1 Weijers, Dolf
YR 2018
UL http://biorxiv.org/content/early/2018/11/27/479113.abstract
AB Multicellular development requires coordinated cell polarization relative to body axes, and translation to oriented cell division. In plants, it is unknown how cell polarities are connected to organismal axes and translated to division. Here, we identify Arabidopsis SOSEKI (SOK) proteins that integrate apical-basal and radial organismal axes to localize to polar cell edges. Localization does not depend on tissue context, requires cell wall integrity and is defined by a transferrable, protein-specific motif. SOK proteins structurally resemble the DIX oligomerization domain in the animal Dishevelled polarity regulator. The DIX-like domain self-interacts and is required for edge localization and for influencing division orientation. Our work identifies a plant compass, interpreted by SOK proteins. Furthermore, despite fundamental differences, polarity in plants and animals converge upon the same protein domain.