RT Journal Article SR Electronic T1 Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.07.21.214346 DO 10.1101/2020.07.21.214346 A1 E.I. Patterson A1 G. Elia A1 A. Grassi A1 A. Giordano A1 C. Desario A1 M. Medardo A1 S.L. Smith A1 E.R. Anderson A1 T. Prince A1 G.T. Patterson A1 E. Lorusso A1 M.S. Lucente A1 G. Lanave A1 S. Lauzi A1 U. Bonfanti A1 A. Stranieri A1 V. Martella A1 F. Solari Basano A1 V.R. Barrs A1 A.D. Radford A1 U. Agrimi A1 G. L. Hughes A1 S. Paltrinieri A1 N. Decaro YR 2020 UL http://biorxiv.org/content/early/2020/07/21/2020.07.21.214346.abstract AB SARS-CoV-2 originated in animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here we report a large-scale study to assess SARS-CoV-2 infection in over 500 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.4% of dogs and 3.9% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.One Sentence Summary SARS-CoV-2 antibodies in pets from Italy.Competing Interest StatementThe authors have declared no competing interest.