TY - JOUR T1 - We think what we eat: Animal-based diet influences cerebral and microbiota networks connectivity in early ages. A study case of an indigenous community in Mexico JF - bioRxiv DO - 10.1101/2020.07.25.221408 SP - 2020.07.25.221408 AU - Ramirez-Carrillo Elvia AU - G-Santoyo Isaac AU - López-Corona Oliver AU - Olga A. Rojas-Ramos AU - Luisa I. Falcón AU - Osiris Gaona AU - Daniel Cerqueda-García AU - Andrés Sánchez-Quinto AU - Rosa María de la Fuente Rodríguez AU - Ariatna Hernández Castillo AU - Nieto Javier Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/07/26/2020.07.25.221408.abstract N2 - We are not individuals, we are much better described as ecosystems due to trillions of bacteria and other microorganisms that inhabit us. We now know that gut microbiota can greatly influence many physiological parameters that in turn may impact several cognitive functions, such as learning, memory, and decision making processes. This mutualistic symbiotic relation known as the gut-brain axis is also constrained by external factors such as dietary habits such as animal protein and lipids intake. Using a novel combination of Machine Learning and Network Theory techniques, we provide evidence from an indigenous population in Guerrero Mexico, that both brain and gut-microbiota connectivity, evaluated by Minimum Spanning Tree as the critical backbone of information flow, diminish under either low protein or lipids intake. We discuss then how this loss of connectivity may translate into a reduction of the individual’s capacity to cope with perturbations as loss of connectivity may be linked with losses in antifragility.Competing Interest StatementThe authors have declared no competing interest. ER -