RT Journal Article
SR Electronic
T1 Tractography Reproducibility Challenge with Empirical Data (TraCED): The 2017 ISMRM Diffusion Study Group Challenge
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 484543
DO 10.1101/484543
A1 Vishwesh Nath
A1 Kurt G. Schilling
A1 Prasanna Parvathaneni
A1 Allison E. Hainline
A1 Yuankai Huo
A1 Justin A. Blaber
A1 Matt Rowe
A1 Paulo Rodrigues
A1 Vesna Prchkovska
A1 Dogu Baran Aydogan
A1 Wei Sun
A1 Yonggang Shi
A1 William A. Parker
A1 Abdol Aziz Ould Ismail
A1 Ragini Verma
A1 Ryan P. Cabeen
A1 Arthur W. Toga
A1 Allen T. Newton
A1 Jakob Wasserthal
A1 Peter Neher
A1 Klaus Maier-Hein
A1 Giovanni Savini
A1 Fulvia Palesi
A1 Enrico Kaden
A1 Ye Wu
A1 Jianzhong He
A1 Yuanjing Feng
A1 Muhamed Barakovic
A1 David Romascano
A1 Jonathan Rafael-Patino
A1 Matteo Frigo
A1 Gabriel Girard
A1 Alessandro Daducci
A1 Jean-Philippe Thiran
A1 Michael Paquette
A1 Francois Rheault
A1 Jasmeen Sidhu
A1 Catherine Lebel
A1 Alexander Leemans
A1 Maxime Descoteaux
A1 Tim B. Dyrby
A1 Hakmook Kang
A1 Bennett A. Landman
YR 2018
UL http://biorxiv.org/content/early/2018/12/03/484543.abstract
AB Purpose Fiber tracking with diffusion weighted magnetic resonance imaging has become an essential tool for estimating in vivo brain white matter architecture. Fiber tracking results are sensitive to the choice of processing method and tracking criteria. Phantom studies provide concrete quantitative comparisons of methods relative to absolute ground truths, yet do not capture variabilities because of in vivo physiological factors.Methods To date, a large-scale reproducibility analysis has not been performed for the assessment of the newest generation of tractography algorithms with in vivo data. Reproducibility does not assess the validity of a brain connection however it is still of critical importance because it describes the variability for an algorithm in group studies. The ISMRM 2017 TraCED challenge was created to fulfill the gap. The TraCED dataset consists of a single healthy volunteer scanned on two different scanners of the same manufacturer. The multi-shell acquisition included b-values of 1000, 2000 and 3000 s/mm2 with 20, 45 and 64 diffusion gradient directions per shell, respectively.Results Nine international groups submitted 46 tractography algorithm entries. The top five submissions had high ICC > 0.88. Reproducibility is high within these top 5 submissions when assessed across sessions or across scanners. However, it can be directly attributed to containment of smaller volume tracts in larger volume tracts. This holds true for the top five submissions where they are contained in a specific order. While most algorithms are contained in an ordering there are some outliers.Conclusion The different methods clearly result in fundamentally different tract structures at the more conservative specificity choices (i.e., volumetrically smaller tractograms). The data and challenge infrastructure remain available for continued analysis and provide a platform for comparison.