PT  - JOURNAL ARTICLE
AU  - Nikolaos Tataridas-Pallas
AU  - Maximillian Thompson
AU  - Alexander Howard
AU  - Ian Brown
AU  - Marina Ezcurra
AU  - Ziyun Wu
AU  - Timo Keurten
AU  - Isabel Goncalves Silva
AU  - T. Keith Blackwell
AU  - Jennifer Tullet
TI  - Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety
AID  - 10.1101/2020.07.21.213504
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.07.21.213504
4099  - http://biorxiv.org/content/early/2020/07/27/2020.07.21.213504.short
4100  - http://biorxiv.org/content/early/2020/07/27/2020.07.21.213504.full
AB  - The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism and respiration, because can mediate the increased lifespan incurred by dietary restriction. We show that actually SKN-1B is not essential for dietary restriction longevity and instead, controls a variety of food-related behaviours. It acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.Competing Interest StatementThe authors have declared no competing interest.