RT Journal Article
SR Electronic
T1 The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.07.29.226829
DO 10.1101/2020.07.29.226829
A1 Lei Zhang
A1 Yanyong Cheng
A1 Shihao Wu
A1 Yufeng Lu
A1 Zhenyu Xue
A1 Dai Chen
A1 Bo Zhang
A1 Zilong Qiu
A1 Hong Jiang
YR 2020
UL http://biorxiv.org/content/early/2020/07/30/2020.07.29.226829.abstract
AB Amygdala is the central brain region governing emotional responses of mammals. However, the detailed molecular taxonomy of amygdala in higher mammals such as primates is still absent. Here we present the molecular taxonomy of amygdala in rhesus monkeys by single-cell RNA sequencing analysis. We found that there are five major cell types in primate amygdala, glutamatergic neurons, GABAergic neurons, astroglia, oligodendrocytes and oligodendrocyte progenitor cells (OPCs). Glutamatergic neurons in the primate amygdala exhibits a great diversity comparing to them in the rodent amygdala. In particular, GABAergic neurons in primate amygdala appeared to be quite unique and contain different cellular composition as them in rodent amygdala. The astroglia in primate amygdala contains two more subtypes comparing to astroglia in rodent amygdala. Taken together, although the evolutionary conservation, the molecular taxonomy study of primate amygdala provides critical insights for understanding the cellular architecture of the primate brain.Competing Interest StatementThe authors have declared no competing interest.