RT Journal Article
SR Electronic
T1 Light remote control of alternative splicing in roots through TOR kinase
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 472126
DO 10.1101/472126
A1 Stefan Riegler
A1 Lucas Servi
A1 Armin Fuchs
A1 Micaela A. Godoy Herz
A1 María G. Kubaczka
A1 Peter Venhuizen
A1 Alois Schweighofer
A1 Craig Simpson
A1 John W.S. Brown
A1 Christian Meyer
A1 Maria Kalyna
A1 Andrea Barta
A1 Ezequiel Petrillo
YR 2018
UL http://biorxiv.org/content/early/2018/12/05/472126.abstract
AB For plants, light is the source of energy and the most relevant regulator of growth and adaptations to the environment by inducing changes in gene expression at various levels, including alternative splicing. Chloroplasts trigger retrograde signals that control alternative splicing in leaves and roots in response to light. Here we provide evidence suggesting that sugars, derived from photosynthesis, act as mobile signals controlling alternative splicing in roots. The inhibition of TOR kinase activity diminishes the alternative splicing response to light and/or sugars in roots, showing the relevance of the TOR pathway in this signaling mechanism. Furthermore, disrupting the function of the mitochondria abolishes alternative splicing changes supporting a key role for these organelles in this signaling axis. We conclude that sugars can act as mobile signals coordinating alternative splicing responses to light throughout the whole plant, exerting this function in roots by activating the TOR pathway.Graphical Abstract Art by Dr. Luciana Giono.