RT Journal Article
SR Electronic
T1 Establishment and imaging evaluation of Guangxi Ba-Ma mini-pigs as a model ofcerebral hernia induced by acute intracranial hypertension
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 487967
DO 10.1101/487967
A1 Jianguo Zhou
A1 Lixuan Huang
A1 Xiaoling Zhu
A1 Wupeng Wei
A1 Yongbiao Feng
A1 Xiangfei Ma
A1 Ling Zhang
A1 Gang Zeng
A1 Jianfeng Zhang
A1 Weixiong Li
A1 Huamin Tang
YR 2018
UL http://biorxiv.org/content/early/2018/12/05/487967.abstract
AB In order to establish an animal model of cerebral hernia induced by acute intracranial hypertension for subsequent research in emergency medicine. Six Guangxi Ba-Ma mini-pigs which were injected with autologous arterial blood by micropump to induce intracranial hematoma in the frontal and temporal parietal lobes. Changes in intracranial pressure (ICP), mean arterial blood pressure (MAP) and cerebral perfusion pressure (CPP)were observed during hematoma formation. Morphological changes and the occupying effects of intracranial hematoma were analyzed using computed tomography (CT) and magnetic resonance imaging (MRI) of the head. ICP, MAP and CPP gradually increased during blood injection, and they began to slowly decrease at 10 min after injection, though they remained higher than before injection. These three parameters were significantly different before blood injection, immediately after injection and at 10 min after injection (P< 0.05). Head CT and MRI showed cerebral hernia induced by acute intracranial hypertension. These results demonstrate micropump injection of autologous arterial blood can lead to acute intracranial hypertension in mini-pigs, which may be a useful model of cerebral hernia.Abbreviations and acronymsCPPcerebral perfusion pressureCTcomputed tomographyECGelectrocardiographyICPintracranial pressureMAPmean arterial blood pressureMRImagnetic resonance imaging