PT  - JOURNAL ARTICLE
AU  - Booker, Chris S
AU  - Coppell, Kirsten J
AU  - Duncan, Ashley
AU  - Kataoka, Minako
AU  - Williams, Sheila M
AU  - Mann, Jim I
TI  - The effect of dietary intervention on inflammatory markers in patients with type 2 diabetes. An analysis of the Lifestyle Over and Above Drugs in Diabetes (LOADD) study
AID  - 10.1101/483412
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 483412
4099  - http://biorxiv.org/content/early/2018/12/07/483412.short
4100  - http://biorxiv.org/content/early/2018/12/07/483412.full
AB  - Ninety-three participants with poorly controlled type 2 diabetes despite optimized drug therapy were randomised to receive intensive dietary advice or usual care for six months. Following dietary intervention a significant reduction in interleukin-18 levels was observed, with a ratio of change (95% CI) of 0.90 (0.82-0.99); p = 0.033. Changes in IL-18 correlated with changes in neopterin, r = 0.299 (p = 0.009)AbbreviationsCRPC-reactive proteinIL-6/10/18interleukins 6 10 or 18IL-18BPinterleukin-18 binding proteinTNFαtumour necrosis factor alphasTNF-R1/2soluble tumour necrosis factor receptors 1 or 2IFN-γinterferon gamma