RT Journal Article
SR Electronic
T1 The effect of dietary intervention on inflammatory markers in patients with type 2 diabetes. An analysis of the Lifestyle Over and Above Drugs in Diabetes (LOADD) study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 483412
DO 10.1101/483412
A1 Booker, Chris S
A1 Coppell, Kirsten J
A1 Duncan, Ashley
A1 Kataoka, Minako
A1 Williams, Sheila M
A1 Mann, Jim I
YR 2018
UL http://biorxiv.org/content/early/2018/12/07/483412.abstract
AB Ninety-three participants with poorly controlled type 2 diabetes despite optimized drug therapy were randomised to receive intensive dietary advice or usual care for six months. Following dietary intervention a significant reduction in interleukin-18 levels was observed, with a ratio of change (95% CI) of 0.90 (0.82-0.99); p = 0.033. Changes in IL-18 correlated with changes in neopterin, r = 0.299 (p = 0.009)AbbreviationsCRPC-reactive proteinIL-6/10/18interleukins 6 10 or 18IL-18BPinterleukin-18 binding proteinTNFαtumour necrosis factor alphasTNF-R1/2soluble tumour necrosis factor receptors 1 or 2IFN-γinterferon gamma