PT - JOURNAL ARTICLE AU - Yihong Zhao AU - R. Todd Constable AU - Denise Hien AU - Tammy Chung AU - Marc N. Potenza TI - Brain Anatomical Covariation Patterns Linked to Binge Drinking and Age at First Full Drink Prior to 21 Years AID - 10.1101/2020.08.02.232942 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.08.02.232942 4099 - http://biorxiv.org/content/early/2020/08/04/2020.08.02.232942.short 4100 - http://biorxiv.org/content/early/2020/08/04/2020.08.02.232942.full AB - Binge drinking and age at first full drink of alcohol prior to 21 years (AFD<21) have been linked to neuroanatomical differences in cortical and subcortical grey matter (GM) volume, cortical thickness, and surface area. Despite the potential to reveal novel network-level relationships, structural covariation patterns among these morphological measures have yet to be examined relative to binge drinking and AFD<21. Here, we used the Joint and Individual Variance Explained (JIVE) method to characterize structural covariation patterns common across and specific to morphological measures in 293 participants (149 individuals with binge drinking and 144 healthy controls) from the Human Connectome Project (HCP). An independent dataset (Nathan Kline Institute Rockland Sample; NKI-RS) was used to examine reproducibility/ generalizability. We identified a highly reproducible joint component dominated by structural covariation between GM volume in the brainstem and thalamus proper, and GM volume and surface area in prefrontal cortical regions. Using linear mixed regression models, we found that this joint component was related to AFD<21 in both the HCP and NKI-RS datasets, whereas the individual thickness component associated with binge drinking and AFD<21 in the HCP dataset was not statistically significant in the NKI-RS sample. Taken together, our results show that a highly reproducible structural pattern involving covariation in brain regions relevant to thalamic-PFC-brainstem neural circuitry is linked to age at first full drink.Competing Interest StatementDr. Potenza has the following disclosures. He has: consulted for and advised Game Day Data, the Addiction Policy Forum, AXA, Idorsia, and Opiant/Lakelight Therapeutics; received research support from the Veteran's Administration, Mohegan Sun Casino, and the National Center for Responsible Gaming (now the International Center for Responsible Gambling); participated in surveys, mailings, or telephone consultations related to addictions, impulse-control disorders or other health topics; consulted for law offices and gambling entities on issues related to impulse control and addictive disorders; provided clinical care in the Connecticut Department of Mental Health and Addiction Services Problem Gambling Services Program; performed grant reviews for the National Institutes of Health and other agencies; edited journals and journal sections; given academic lectures in grand rounds, CME events, and other clinical/scientific venues; and generated books or chapters for publishers of mental health texts. Other authors declare that they have no conflicts of interest.