PT  - JOURNAL ARTICLE
AU  - Yijun Wang
AU  - Jinbao Huang
AU  - Yong Sun
AU  - Jun He
AU  - Weiwei Li
AU  - Zhirong Liu
AU  - Ethan Will Taylor
AU  - Margaret P Rayman
AU  - Xiaochun Wan
AU  - Jinsong Zhang
TI  - SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis
AID  - 10.1101/2020.07.31.230243
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.07.31.230243
4099  - http://biorxiv.org/content/early/2020/08/04/2020.07.31.230243.short
4100  - http://biorxiv.org/content/early/2020/08/04/2020.07.31.230243.full
AB  - A significant, positive association between selenium status and prognosis of SARS-CoV-2 infection has been identified among COVID-19 patients in China. Moreover, a German study revealed a pronounced deficit of serum selenium and SELENOP concentrations in COVID-19 patients, and selenium deficiency was associated with mortality risk from COVID-19. The present study investigated the influence of SARS-CoV-2 on gene expression of host selenoproteins which mediate many beneficial actions of selenium. We found that SARS-CoV-2 suppressed mRNA expression of selenoproteins associated with ferroptosis (GPX4), endoplasmic reticulum stress (SELENOF, SELENOK, SELENOM and SELENOS) and DNA synthesis (TXNRD3), while SARS-CoV-2 increased gene expression of IL-6 (an inflammatory cytokine positively correlated with severity of COVID-19), in Vero cells. These results provide a deeper insight into the connection between selenium and SARS-CoV-2 pathogenesis.Competing Interest StatementThe authors have declared no competing interest.