RT Journal Article
SR Electronic
T1 Reduced signal for polygenic adaptation of height in UK Biobank
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 354951
DO 10.1101/354951
A1 Jeremy J. Berg
A1 Arbel Harpak
A1 Nasa Sinnott-Armstrong
A1 Anja Moltke Jørgensen
A1 Hakhamanesh Mostafavi
A1 Yair Field
A1 Evan A. Boyle
A1 Xinjun Zhang
A1 Fernando Racimo
A1 Jonathan K. Pritchard
A1 Graham Coop
YR 2018
UL http://biorxiv.org/content/early/2018/12/10/354951.abstract
AB Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK Biobank (UKB), a large, independent dataset. We find that the signals of selection using UKB effect-size estimates for height are strongly attenuated or absent. We also provide evidence that previous analyses were confounded by population stratification Therefore, the conclusion of strong polygenic adaptation now lacks support. Moreover, these discrepancies highlight (1) that methods for correcting for population stratification in GWAS may not always be sufficient for polygenic trait analyses, and (2) that claims of differences in polygenic scores between populations should be treated with caution until these issues are better understood.