PT  - JOURNAL ARTICLE
AU  - Filman, David J.
AU  - Marino, Stephen F.
AU  - Ward, Joy E.
AU  - Yang, Lu
AU  - Mester, Zoltán
AU  - Bullitt, Esther
AU  - Lovley, Derek R.
AU  - Strauss, Mike
TI  - Structure of a cytochrome-based bacterial nanowire
AID  - 10.1101/492645
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 492645
4099  - http://biorxiv.org/content/early/2018/12/10/492645.short
4100  - http://biorxiv.org/content/early/2018/12/10/492645.full
AB  - Electrically conductive pili from Geobacter species, termed bacterial “nanowires”, are intensely studied for their biological significance and potential in the development of new materials. We have characterized a unique nanowire from conductive G. sulfurreducens pili preparations by cryo-electron microscopy composed solely of the c-type cytochrome OmcS. We present here, at 3.4 Å resolution, a novel structure of a cytochrome-based filament and discuss its possible role in long-range biological electron transport.Summary sentence Cryo-electron microscopy reveals the remarkable assembly of a c-type cytochrome into filaments comprising a heme-based bacterial nanowire.