TY - JOUR T1 - Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique JF - bioRxiv DO - 10.1101/2020.08.05.237503 SP - 2020.08.05.237503 AU - Selena Alonso AU - Marta Vidal AU - Gemma Ruiz-Olalla AU - Raquel González AU - M. Nelia Manaca AU - Chenjerai Jairoce AU - Miquel Vázquez-Santiago AU - Reyes Balcells AU - Anifa Vala AU - María Ruperez AU - Pau Cisteró AU - Laura Fuente-Soro AU - Marta Cova AU - Evelina Angov AU - Arsenio Nhacolo AU - Esperança Sevene AU - John J. Aponte AU - Eusébio Macete AU - Ruth Aguilar AU - Alfredo Mayor AU - Clara Menéndez AU - Carlota Dobaño AU - Gemma Moncunill Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/08/07/2020.08.05.237503.abstract N2 - Antibody transplacental transfer is essential for conferring protection in newborns against infectious diseases. This transfer may be affected by gestational age and maternal infections, although the effects are not consistent across studies. We measured total IgG and IgG subclasses by quantitative suspension array technology against fourteen pathogens and vaccine antigens, including target of maternal immunization, in 341 delivering HIV− and HIV+ mother-infant pairs from southern Mozambique. Maternal antibody levels were the main determinant of cord antibody levels. HIV broadly reduced the placental transfer and cord levels of IgG and IgG1, but also IgG2 to half of the antigens. Plasmodium falciparum exposure and prematurity were negatively associated with cord antibody levels and placental transfer but this was antigen-subclass dependent. These findings suggest maternal infections may impact the efficacy of maternal immunization and confirm the lower transfer of antibodies as one of the causes underlying increased susceptibility to infections in HIV-exposed infants. ER -