RT Journal Article
SR Electronic
T1 Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.08.05.237503
DO 10.1101/2020.08.05.237503
A1 Selena Alonso
A1 Marta Vidal
A1 Gemma Ruiz-Olalla
A1 Raquel González
A1 M. Nelia Manaca
A1 Chenjerai Jairoce
A1 Miquel Vázquez-Santiago
A1 Reyes Balcells
A1 Anifa Vala
A1 María Ruperez
A1 Pau Cisteró
A1 Laura Fuente-Soro
A1 Marta Cova
A1 Evelina Angov
A1 Arsenio Nhacolo
A1 Esperança Sevene
A1 John J. Aponte
A1 Eusébio Macete
A1 Ruth Aguilar
A1 Alfredo Mayor
A1 Clara Menéndez
A1 Carlota Dobaño
A1 Gemma Moncunill
YR 2020
UL http://biorxiv.org/content/early/2020/08/07/2020.08.05.237503.abstract
AB Antibody transplacental transfer is essential for conferring protection in newborns against infectious diseases. This transfer may be affected by gestational age and maternal infections, although the effects are not consistent across studies. We measured total IgG and IgG subclasses by quantitative suspension array technology against fourteen pathogens and vaccine antigens, including target of maternal immunization, in 341 delivering HIV− and HIV+ mother-infant pairs from southern Mozambique. Maternal antibody levels were the main determinant of cord antibody levels. HIV broadly reduced the placental transfer and cord levels of IgG and IgG1, but also IgG2 to half of the antigens. Plasmodium falciparum exposure and prematurity were negatively associated with cord antibody levels and placental transfer but this was antigen-subclass dependent. These findings suggest maternal infections may impact the efficacy of maternal immunization and confirm the lower transfer of antibodies as one of the causes underlying increased susceptibility to infections in HIV-exposed infants.