@article {Shah485789, author = {Niraj Shah and Tomomi Wakabayashi and Yasuko Kawamura and Cathrine Kiel Skovbjerg and Ming-Zhuo Wang and Yusdar Mustamin and Yoshiko Isomura and Vikas Gupta and Haojie Jin and Terry Mun and Niels Sandal and Fuyuki Azuma and Eigo Fukai and {\"U}mit Seren and Shohei Kusakabe and Yuki Kikuchi and Shogo Nitanda and Takashi Kumaki and Mads S{\o}nderk{\ae}r and Kaare Lehmann Nielsen and Korbinian Schneeberger and Jens Stougaard and Shusei Sato and Mikkel Heide Schierup and Stig Uggerh{\o}j Andersen}, title = {Extreme genetic signatures of local adaptation during plant colonization}, elocation-id = {485789}, year = {2018}, doi = {10.1101/485789}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Colonization of new habitats is expected to require genetic adaptations to overcome environmental challenges. Here we use full genome re-sequencing and extensive common garden experiments to investigate demographic and selective processes associated with the recent colonization of Japan by Lotus japonicus. We carefully track the colonization process where L. japonicus gradually spread from subtropical conditions to much colder climates in northern Japan. We characterize the loss of diversity during this process and identify genomic regions with extreme genetic differentiation. Next, we perform population structure-corrected association mapping of phenotypic traits measured in a common garden and discover a number of genome-wide significant associations. Contrasting these analyses, we find that there is a strong concordance between phenotypic variation and extreme differentiation for overwintering and flowering time traits. Our results provide evidence that these traits were direct targets of selection by local adaptation during the colonization process and point to associated candidate genes.}, URL = {https://www.biorxiv.org/content/early/2018/12/11/485789}, eprint = {https://www.biorxiv.org/content/early/2018/12/11/485789.full.pdf}, journal = {bioRxiv} }