TY - JOUR T1 - Organizing principles of whole-brain functional connectivity in zebrafish larvae JF - bioRxiv DO - 10.1101/496414 SP - 496414 AU - Richard F. Betzel Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/12/15/496414.abstract N2 - Network science has begun to reveal the fundamental principles by which large-scale brain networks are organized, including geometric constraints, a balance between segregative and integrative features, and flexible brain areas. However, it remains unknown whether whole-brain networks imaged at the cellular level are organized according to similar principles. Here, we analyze whole-brain functional networks reconstructed from calcium imaging data recorded in larval zebrafish. Our analyses reveal that functional connections are distance-dependent and that networks exhibit hierarchical modular structure and hubs that span module boundaries. We go on to show that spon-taneous network structure places constraints on stimulus-evoked reconfigurations of connections and that networks are highly consistent across individuals. Our analyses reveal, for the first time, basic organizing principles of whole-brain functional brain networks at the microscale. Our overarching methodological framework provides a blueprint for studying the correlated activity at the cellular level using a low-dimensional network representation. Our work forms a conceptual bridge between macro- and microscale network neuroscience and opens myriad paths for future studies to investigate network structure of nervous systems at the cellular level. ER -