PT  - JOURNAL ARTICLE
AU  - Guanjue Xiang
AU  - Belinda Giardine
AU  - Lin An
AU  - Chen Sun
AU  - Cheryl A. Keller
AU  - Elisabeth Heuston
AU  - David Bodine
AU  - Ross C Hardison
AU  - Yu Zhang
TI  - Snapshot: clustering and visualizing epigenetic history during cell differentiation
AID  - 10.1101/291880
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 291880
4099  - http://biorxiv.org/content/early/2018/12/19/291880.short
4100  - http://biorxiv.org/content/early/2018/12/19/291880.full
AB  - Epigenetic modification of chromatin plays a pivotal role in regulating gene expression during cell differentiation. The scale and complexity of epigenetic data pose significant challenges for biologists to identify the regulatory events controlling cell differentiation. Here, we present a new method, called Snapshot, that uses epigenetic data to generate a hierarchical visualization for DNA regions with epigenetic features segregating along any given cell differentiation hierarchy of interest. Different hierarchies of cell types may be used to highlight the epigenetic history specific to any particular cell lineage. We demonstrate the utility of Snapshot using data from the VISION project, an international project for ValIdated Systematic IntegratiON of epigenomic data in mouse and human hematopoiesis.Availability and implementation: https://github.com/guanjue/snapshot