TY - JOUR T1 - Boosting learning efficacy with non-invasive brain stimulation in intact and brain-damaged humans JF - bioRxiv DO - 10.1101/500215 SP - 500215 AU - F. Herpich AU - M.D. Melnick AU - S. Agosta AU - K.R. Huxlin AU - D. Tadin AU - L. Battelli Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/12/19/500215.abstract N2 - Numerous behavioral studies have shown that visual function can improve with training, although perceptual refinements generally require weeks to months of training to attain. This, along with questions about long-term retention of learning, limits practical and clinical applications of many such paradigms. Here, we show for the first time that just 10 days of visual training coupled with transcranial random noise stimulation (tRNS) over visual areas causes dramatic improvements in visual motion perception. Relative to control conditions and anodal stimulation, tRNS-enhanced learning was at least twice as fast, and, crucially, it persisted for 6 months after the end of training and stimulation. Notably, tRNS also boosted learning in patients with chronic cortical blindness, leading to recovery of motion processing in the blind field after just 10 days of training, a period too short to elicit enhancements with training alone. In sum, our results reveal a remarkable enhancement of the capacity for long-lasting plastic and restorative changes when a neuromodulatory intervention is coupled with visual training. ER -