RT Journal Article
SR Electronic
T1 Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.08.18.255240
DO 10.1101/2020.08.18.255240
A1 Satoshi Watanabe
A1 Tohru Kurotani
A1 Tomofumi Oga
A1 Jun Noguchi
A1 Risa Isoda
A1 Akiko Nakagami
A1 Kazuhisa Sakai
A1 Keiko Nakagaki
A1 Kayo Sumida
A1 Kohei Hoshino
A1 Koichi Saito
A1 Izuru Miyawaki
A1 Masayuki Sekiguchi
A1 Keiji Wada
A1 Takafumi Minamimoto
A1 Noritaka Ichinohe
YR 2020
UL http://biorxiv.org/content/early/2020/08/18/2020.08.18.255240.abstract
AB Autism spectrum disorder (ASD) is a synapse-related disorder that is diagnosed at around 3 years of age. Earlier intervention is desirable for better ASD prognosis; however, there is limited biological literature regarding early-age ASD. This study aimed to assess altered cortical synapses and gene expression in the ASD model marmoset. There were distinct phenotypes in the model animals across the neonate, childhood, and mature stages in the dorsomedial prefrontal cortex (Brodmann area 8b/9). At the neonate stage, synapses were underdeveloped and modulated genes were enriched with synaptogenesis- and ASD-related genes. At the childhood stage, synaptic features and gene expressions associated with experience-dependent circuit remodeling were altered in model animals. At the mature stage, there were synapse overdevelopment and altered gene expression similar to those in human ASD. These early synaptic phenotypes and altered gene expressions could be novel targets of efficient therapy from a young age.Competing Interest StatementThe authors have declared no competing interest.