PT  - JOURNAL ARTICLE
AU  - Qiannan Xu
AU  - Lihong Chen
AU  - Li Zhang
AU  - Mengyan Hu
AU  - Xiaopan Wang
AU  - Qi Yang
AU  - Yunchen Le
AU  - Feng Xue
AU  - Xia Li
AU  - Jie Zheng
TI  - Pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection
AID  - 10.1101/2020.06.30.181297
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.06.30.181297
4099  - http://biorxiv.org/content/early/2020/08/23/2020.06.30.181297.short
4100  - http://biorxiv.org/content/early/2020/08/23/2020.06.30.181297.full
AB  - Since the end of 2019, COVID-19 pandemic caused by the SARS-CoV-2 emerged globally. The angiotensin-converting enzyme 2 (ACE2) on the cell surface is crucial for SARS-COV-2 entering into the cells. We use SARS-COV-2 pseudo virus and humanized ACE2 mice to mimic the possible transmitting of SARS-COV-2 through skin based on the data we found that skin ACE2 level is associated with skin pre-existing cutaneous conditions in human and mouse models and inflammatory skin disorders with barrier dysfunction increased the penetration of topical FITC conjugated spike protein into the skin. Our study indicated the possibility that the pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection.Competing Interest StatementThe authors have declared no competing interest.