RT Journal Article
SR Electronic
T1 Pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.30.181297
DO 10.1101/2020.06.30.181297
A1 Qiannan Xu
A1 Lihong Chen
A1 Li Zhang
A1 Mengyan Hu
A1 Xiaopan Wang
A1 Qi Yang
A1 Yunchen Le
A1 Feng Xue
A1 Xia Li
A1 Jie Zheng
YR 2020
UL http://biorxiv.org/content/early/2020/08/23/2020.06.30.181297.abstract
AB Since the end of 2019, COVID-19 pandemic caused by the SARS-CoV-2 emerged globally. The angiotensin-converting enzyme 2 (ACE2) on the cell surface is crucial for SARS-COV-2 entering into the cells. We use SARS-COV-2 pseudo virus and humanized ACE2 mice to mimic the possible transmitting of SARS-COV-2 through skin based on the data we found that skin ACE2 level is associated with skin pre-existing cutaneous conditions in human and mouse models and inflammatory skin disorders with barrier dysfunction increased the penetration of topical FITC conjugated spike protein into the skin. Our study indicated the possibility that the pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection.Competing Interest StatementThe authors have declared no competing interest.