RT Journal Article
SR Electronic
T1 Differential expression of microRNAs in Alzheimer’s disease brain, blood and cerebrospinal fluid: a systematic review and meta-analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 499491
DO 10.1101/499491
A1 Petros Takousis
A1 Angélique Sadlon
A1 Jessica Schulz
A1 Inken Wohlers
A1 Valerija Dobricic
A1 Lefkos Middleton
A1 Christina M. Lill
A1 Robert Perneczky
A1 Lars Bertram
YR 2018
UL http://biorxiv.org/content/early/2018/12/27/499491.abstract
AB INTRODUCTION Several microRNAs (miRNAs) have been implicated in Alzheimer’s disease (AD) pathogenesis but the evidence from individual case-control-studies remains inconclusive.METHODS A systematic literature review was performed, followed by standardised multi-stage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal fluid (CSF) specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty.RESULTS Data from 147 independent datasets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed study-wide significant differential expression (α<1.08×10−4) in brain, CSF, and blood-derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. Of these 57 miRNAs, 13 had not been reported in the abstracts of previous original or review articles.DISCUSSION Our systematic assessment of differential miRNA expression is the first of its kind in AD and highlights miRNAs of relevance.