PT  - JOURNAL ARTICLE
AU  - Narges Dargahi
AU  - Joshua Johnson
AU  - Vasso Apostolopoulos
TI  - Immune modulatory effects of probiotic <em>Streptococcus thermophilus</em> on human monocytes
AID  - 10.1101/2020.08.27.271346
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.08.27.271346
4099  - http://biorxiv.org/content/early/2020/08/28/2020.08.27.271346.short
4100  - http://biorxiv.org/content/early/2020/08/28/2020.08.27.271346.full
AB  - Ingesting probiotics contributes to the development of a healthy microflora in the gastrointestinal tract with established benefits to human health. Some of these beneficial effects may be through modulating of the immune system and probiotics have become more common in the treatment of many inflammatory and immune disorders. We demonstrate a range of immune modulating effects of Streptococcus thermophilus by human monocytes, including, decreased mRNA expression of IL-1R, IL-18, IFNγR1, IFNαR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, ITGAM, SLC11A1, and, increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. Routine administration of Streptococcus thermophilus in fermented dairy products, and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.