RT Journal Article
SR Electronic
T1 A novel humanized mouse model to study mucosal HIV-1 transmission and prevention
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.08.31.274167
DO 10.1101/2020.08.31.274167
A1 Kanika Vanshylla
A1 Kathrin Held
A1 Tabea M. Eser
A1 Henning Gruell
A1 Kanika Jain
A1 Daniela Weiland
A1 Jan Muench
A1 Berthold Gruettner
A1 Christof Geldmacher
A1 Florian Klein
YR 2020
UL http://biorxiv.org/content/early/2020/08/31/2020.08.31.274167.abstract
AB Humanized mice have been critical for HIV-1 research, but are inefficient at mucosal HIV-1 transmission. We present a fetal tissue-independent model called CD34T+ with enhanced human leukocyte levels in the blood and improved T cell homing to the gut-associated lymphoid tissue. CD34T+ mice are highly permissive to intra-rectal HIV-1 infection, which can be prevented by infusion of broadly neutralizing antibodies. Therefore, CD34T+ mice provide a novel platform for mucosal HIV-1 transmission and prevention studies.Competing Interest StatementThe authors have declared no competing interest.