PT  - JOURNAL ARTICLE
AU  - Kevin D. Hall
AU  - Juen Guo
TI  - Carbs versus fat: does it really matter for maintaining lost weight?
AID  - 10.1101/476655
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 476655
4099  - http://biorxiv.org/content/early/2019/01/03/476655.short
4100  - http://biorxiv.org/content/early/2019/01/03/476655.full
AB  - Key MessagesThe latest battle in the perpetual diet wars claimed that low carbohydrate diets offer a metabolic advantage to burn more calories and thereby help patients maintain lost weight.However, analyzing the data according to the original pre-registered statistical plan resulted in no statistically significant effects of diet composition on energy expenditure.The large reported diet effects on energy expenditure calculated using the revised analysis plan depended on data from subjects with excessive amounts of unaccounted energy. Adjusting the data to be commensurate with energy conservation resulted in a diet effect that was less than half the value reported in the BMJ paper.Diet adherence is key to sustained weight loss, and no diet has yet demonstrated a clinically meaningful superiority for long-term maintenance of lost weight. More research is required to better understand the factors that sustain healthful diet changes over the long-term.