TY - JOUR T1 - Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum JF - bioRxiv DO - 10.1101/2020.09.02.279240 SP - 2020.09.02.279240 AU - Enrica Montalban AU - Albert Giralt AU - Lieng Taing AU - Yuki Nakamura AU - Claire Martin AU - Benoit de Pins AU - Assunta Pelosi AU - Laurence Goutebroze AU - Laia Castell AU - Wei Wang AU - Kathrina Daila Neiburga AU - Letizia Vestito AU - Angus C. Nairn AU - Emmanuel Valjent AU - Denis Hervé AU - Nathaniel Heintz AU - Nicolas Gambardella Le Novère AU - Paul Greengard AU - Jean-Pierre Roussarie AU - Jean-Antoine Girault Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/09/03/2020.09.02.279240.abstract N2 - Forebrain dopaminoceptive neurons play a key role in movement, action selection, motivation, and working memory. Their activity is dysregulated in addiction, Parkinson’s disease and other conditions. To characterize the diverse dopamine target neuronal populations, we compare translating mRNAs in neurons of dorsal striatum and nucleus accumbens expressing D1 or D2 dopamine receptor and prefrontal cortex expressing D1 receptor. We identify D1/D2 and striatal dorso-ventral differences in the translational and splicing landscapes, which establish the characteristics of dopaminoceptive neurons. Expression differences and network analyses identify novel transcription factors with presumptive roles in these differences. Prostaglandin E2 appears as a candidate upstream regulator in the dorsal striatum, a hypothesis supported by converging functional evidence indicating its role in enhancing D2 dopamine receptor action. Our study provides powerful resources for characterizing dopamine target neurons, new information about striatal gene expression patterns, and reveals the unforeseen role of prostaglandin E2 in the dorsal striatum.Competing Interest StatementThe authors have declared no competing interest. ER -