RT Journal Article
SR Electronic
T1 Genetic surfing in human populations: from genes to genomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 055145
DO 10.1101/055145
A1 Stephan Peischl
A1 Isabelle Dupanloup
A1 Lars Bosshard
A1 Laurent Excoffier
YR 2016
UL http://biorxiv.org/content/early/2016/05/24/055145.abstract
AB Genetic surfing describes the spatial spread and increase in frequency of variants that are not lost by genetic drift and serial migrant sampling during a range expansion. Genetic surfing does not modify the total number of derived alleles in a population or in an individual genome, but it leads to a loss of heterozygosity along the expansion axis, implying that derived alleles are more often in homozygous state. Genetic surfing also affects selected variants on the wave front, making them behave almost like neutral variants during the expansion. In agreement with theoretical predictions, human genomic data reveals an increase in recessive mutation load with distance from Africa, an expansion load likely to have developed during the expansion of human populations out of Africa.