PT  - JOURNAL ARTICLE
AU  - S. Buccelli
AU  - Y. Bornat
AU  - I. Colombi
AU  - M. Ambroise
AU  - L. Martines
AU  - V. Pasquale
AU  - M. Bisio
AU  - J. Tessadori
AU  - P. Nowak
AU  - F. Grassia
AU  - A. Averna
AU  - M. Tedesco
AU  - P. Bonifazi
AU  - F. Difato
AU  - P. Massobrio
AU  - T. Levi
AU  - M. Chiappalone
TI  - A neuroprosthetic system to restore neuronal communication in modular networks
AID  - 10.1101/514836
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 514836
4099  - http://biorxiv.org/content/early/2019/01/09/514836.short
4100  - http://biorxiv.org/content/early/2019/01/09/514836.full
AB  - Recent advances in neurotechnology allow neurological impairments to be treated or reduced by brain machine interfaces and neuroprostheses. To develop energy-efficient and real-time capable devices, neuromorphic computing systems are envisaged as the core of next-generation ‘neurobiohybrid’ systems for brain repair. We demonstrate here the first exploitation of a neuromorphic prosthesis to restore bidirectional interactions between two neuronal populations, even when one is damaged or completely missing. We used in vitro modular cell cultures to mimic the mutual interaction between neuronal assemblies and created a focal lesion to functionally disconnect the two populations. Then, we employed our neuromorphic prosthesis for two specific applications with future clinical implications: bidirectional bridging to artificially reconnect two disconnected neuronal modules and hybrid bidirectional bridging to replace the activity of one module with a neuromorphic spiking neural network. Our neuroprosthetic system opens up new avenues for the development of novel bioelectrical therapeutics for human applications.