PT  - JOURNAL ARTICLE
AU  - Carlos Padilla-Rojas
AU  - Karolyn Vega-Chozo
AU  - Marco Galarza-Perez
AU  - Henri Bailon Calderon
AU  - Priscila Lope-Pari
AU  - Johanna Balbuena-Torres
AU  - David Garcia Neyra
AU  - Maribel Huaringa-Nuñez
AU  - Nancy Rojas-Serrano
AU  - Omar A. Caceres-Rey
TI  - Genomic analysis reveals local transmission of SARS-CoV-2 in early pandemic phase in Peru
AID  - 10.1101/2020.09.05.284604
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.09.05.284604
4099  - http://biorxiv.org/content/early/2020/09/06/2020.09.05.284604.short
4100  - http://biorxiv.org/content/early/2020/09/06/2020.09.05.284604.full
AB  - The dissemination of cases of the new SAR-COV-2 coronavirus represents a serious public health problem for Latin America and Peru. For this reason, it is important to characterize the genome of the isolates that circulate in Latin America. To characterize the complete genome of first samples of the virus circulating in Peru, we amplified seven overlapping segments of the viral genome by RT-PCR and sequenced using Miseq platform. The results indicate that the genomes of the Peruvian SARS-COV-2 samples belong to the genetic groups G and S. Likewise, a phylogenetic and MST analysis of the isolates confirm the introduction of multiple isolates from Europe and Asia that, after border closing, were transmitted locally in the capital and same regions of the country. These Peruvian samples (56%) grouped into two clusters inside G clade and share B.1.1.1 lineage. The characterization of these isolates must be considered for the use and design of diagnostic tools, and effective treatment and vaccine formulations.Competing Interest StatementThe authors have declared no competing interest.