RT Journal Article
SR Electronic
T1 β-catenin dependent axial patterning in Cnidaria and Bilateria uses similar regulatory logic
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.08.287821
DO 10.1101/2020.09.08.287821
A1 Tatiana Bagaeva
A1 Andrew J. Aman
A1 Thomas Graf
A1 Isabell Niedermoser
A1 Bob Zimmermann
A1 Yulia Kraus
A1 Magdalena Schatka
A1 Adrien Demilly
A1 Ulrich Technau
A1 Grigory Genikhovich
YR 2020
UL http://biorxiv.org/content/early/2020/09/08/2020.09.08.287821.abstract
AB In animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which enables correct positioning of the anatomical structures. The most ancient axis patterning system acting across animal phyla relies on β-catenin signaling, which directs gastrulation, and patterns the main body axis. However, within Bilateria, the patterning logic varies significantly between protostomes and deuterostomes. To deduce the ancestral principles of β-catenin dependent axial patterning, we investigated the oral-aboral axis patterning in the sea anemone Nematostella - a member of the bilaterian sister group Cnidaria. Here we elucidate the regulatory logic by which more orally expressed β-catenin targets repress more aborally expressed β- catenin targets, and progressively restrict the initially global, maternally provided aboral identity. Similar regulatory logic of β-catenin-dependent patterning in Nematostella and deuterostomes suggests a common evolutionary origin of these processes.Competing Interest StatementThe authors have declared no competing interest.